1. Prague Castle-For most travelers, the focal point of a visit to the Czech Republic is Prague Castle (Pražský hrad). It's on all Prague itineraries. Located in the city's Hradcany neighborhood and dating from the late 10th century.
2. Prague's Charles Bridge-This famous structure spanning the River Vltava was built in 1357 and has many unique points of interest along its 520-meter span, including numerous fine statues. Perhaps the most famous are those of the bridge's namesake.
3. St. Vitus Cathedral-Part of the Prague Castle complex, St. Vitus Cathedral is best known as the home of the Bohemian Coronation Jewels, as well as the tomb of the Czech people's most revered saint, St. Wenceslas.
4. Prague's Old Town Square & Wenceslas Square-Prague's Old Town Square was the city's first market. Situated at the intersection of trade routes, it still has buildings dating back to the 10th century.
5. Ceský Krumlov Castle-Dominating the old town after which it's named, Ceský Krumlov Castle is remarkably well preserved given its age. Dating from the 13th century, much of what stands today in this UNESCO World.
6. Brno's Cathedral of St. Peter and Paul-The site of the cathedral first held an 11th-century Romanesque chapel that was later expanded to include a crypt and a basilica, the remains of which can still be seen.
7. Bone Collectors-Spread across the Czech Republic are a number of fascinating locations dedicated to preserving the remains of those slain in war or killed by diseases such as the terrible plagues that gripped Europe in medieval times.
8. The Colonnades and Spas of Karlovy Vary-Often referred to by its old German name of Karlsbad, Karlovy Vary is a must-visit for anyone interested in an authentic European spa experience.