Japanese researchers identify protein with potential to prevent aging

[{"selector":"#anim-3c8080ff-e62e-4ecf-9796-4836d2012392","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-6c1059c9-14a2-4bba-bc5b-4c23e11a6ce9","keyframes":{"transform":["rotate(-360deg) translate3d(114.50150%, 0px, 0) rotate(360deg)","rotate(-360deg) translate3d(0px, 0px, 0) rotate(360deg)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] HKDC1's Role : Protein HKDC1 aids in maintaining mitochondria and lysosomes, crucial for cell health.

Response to Stress: HKDC1 becomes more active during cellular stress, particularly within mitochondria or lysosomes.

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TFEB's Target: Researchers found that TFEB targets the HKDC1 gene, regulating its activity under stress conditions

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[{"selector":"#anim-1af7d51f-1719-4076-9e9a-2cf890779a24","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-468667bd-e65a-48e8-9a86-bedba60908f4","keyframes":{"transform":["translate3d(114.87342%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Mitophagy Assistance : HKDC1's interaction with TOM20, an outer mitochondrial protein

[{"selector":"#anim-9854bb84-b183-42c8-be15-7dc6ef09ddb3","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-2832abe5-cbef-4e56-a456-49247cd99ac6","keyframes":{"transform":["translate3d(114.55696%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Lysosomal Repair : HKDC1's localization in mitochondria is critical for lysosomal repair; reduced HKDC1 disrupts lysosomal cleanup

[{"selector":"#anim-f7edb3da-a3ad-4df9-b6c4-1acdf997eed9","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-5a108cb2-0021-41b4-8505-767b18a1ad91","keyframes":{"transform":["translate3d(119.42676%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] VDAC Interaction : HKDC1's role involves interacting with VDACs, proteins linking mitochondria and lysosomes

[{"selector":"#anim-2d0dbdca-48c5-4dfb-85d8-54a68de5f559","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-f19a4c4e-47b4-423c-a326-cc88b39312af","keyframes":{"transform":["translate3d(115.28663%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Preventing Cellular Senescence : HKDC1's multifaceted functions prevent cellular aging and maintain organelle integrity.

[{"selector":"#anim-76bd6946-c0fa-4a43-945c-a89a2ccd316c","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-21bd0ec0-c461-48ba-8078-fbf4e11573b1","keyframes":{"transform":["translate3d(115.28663%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Therapeutic Potential : Understanding HKDC1's pivotal role opens new therapeutic avenues targeting age-related diseases linked to organelle malfunction

Japanese researchers identify protein with potential to prevent aging

Response to Stress: HKDC1 becomes more active during cellular stress, particularly within mitochondria or lysosomes.

TFEB's Target: Researchers found that TFEB targets the HKDC1 gene, regulating its activity under stress conditions

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